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Oligonucleotide Design Lead

Madrid, Spain | May 17, 2026

Report as Closed

Company: GRUNENTHAL PHARMA, S,A,

Country: Spain

Salary: $416,981 - $833,962

Type: Onsite

Employment: Contract

Description:

  • Lead the design and computational optimisation of RNA therapeutics, particularly siRNA, integrating RNA biology with oligonucleotide chemistry to enable gene knockdown and RNA regulatory approaches, including up-regulation strategies.
  • Define and prioritise target sites and design strategies by integrating sequence features, RNA accessibility, transcript structure, cross-species alignment, and emerging experimental data
  • Drive iterative design–test–learn cycles by analysing and rapidly integrating datasets linking sequence, chemistry, and biological activity to inform decision-making
  • Develop and apply computational tools and workflows (e.g. Python or R) to enable scalable oligonucleotide design, data integration, and rapid sequence–chemistry iteration
  • Partner closely with oligonucleotide chemists and delivery scientists to co-optimise sequence, chemical modifications, and delivery approaches to maximise potency, durability, and tissue activity
  • Lead and contribute to discovery programs advancing RNA therapeutic candidates toward candidate profiling and clinical development, while helping prioritise and evaluate new targets aligned with platform capabilities.
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